Long-term human IgG treatment improves heart and muscle function in a mouse model of Duchenne muscular dystrophy


Jana Zschüntzsch, Pia Vanessa Jouvenal, Yaxin Zhang, Florian Klinker, Malte Tiburcy, David Liebetanz, Dörthe Malzahn, Heinrich Brinkmeier & Jens Schmidt

Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease caused by mutations in the dystrophin gene, which leads to structural instability of the dystrophin–glycoprotein-complex with subsequent muscle degeneration. In addition, muscle inflammation has been implicated in disease progression and therapeutically addressed with glucocorticosteroids. These have numerous adverse effects. Treatment with human immunoglobulin G (IgG) improved clinical and para-clinical parameters in the early disease phase in the well-established mdx mouse model. The aim of the present study was to confirm the efficacy of IgG in a long-term pre-clinical study in mdx mice.

Published: 25 February 2020
Journal: Journal of Cachexia, Sarcopenia and Muscle

Link: doi.org/10.1002/jcsm.12569

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